to yellowish clear liquid.
【Pharmacological effect】Pharmacodynamic: Florfenicol belongs to a group of the
amide alcohols broad-spectrum antimicrobials
, which has a strong antibacterial activity to a
variety of gram-positive bacteria, gram-negative bacteria, mycoplasma, etc. Florfenicol
is primarily a bacteriostatic agent inhibiting bacterial protein synthesis by
binding to ribosomal 50S subunit. The antibacterial activity of florfenicol is similar
to or stronger than that of chloramphenicol and thiamphenicol against
microorganisms. Chloramphenicol resistance bacteria resulting from acetylation
are still likely to be sensitive to florfenicol, such as E. coli, Klebsiella
pneumoniae, etc. Pasteurella hemolytica, Pasteurella multocida and Actinobacillus pleuropneumoniae are highly
sensitive to florfenicol.
Florfenicol can be rapidly
absorbed via intramuscular
injection, reach the therapeutic
concentrations in blood approximately 1 hour and achieve the highest plasma drug concentration
in 1-3 hours. The bioavailability of this product is over 80%. Florfenicol can
be distributed in wide range of tissue in animals and can pass through the
blood-brain barrier. The drug prototype will be primarily
excreted through urine and small amount excreted by faeces.
Florfenicol is not compatible with macrolides and lincosamides , therefore,
they should not be used simultanenously.
(2) Florfenicol might have antagonistic
effects in combination with bactericidal activity of penicillin or
aminoglycosides, however, it has not yet been demonstrated in animals.
【Indications】 It is mainly used for the treatment of bacterial diseases
caused by sensitive bacteria for pigs and chickens,
such as porcine infectious pleuropneumonia, typhoid fever and paratyphoid fever
caused by Salmonella. It can be also
used for treatment of chicken cholera, pullorum disease and colibacillosis,
【Usage and dosage】Intramuscular
injection: 0.2 mL/ kg of body weight each time for pigs, chickens and 2 consecutive times with 48 hours interval.
【Adverse reaction】Overdosage may
have some immunosuppressive effects.
(1) It is not recommended for laying hens in
the laying period.
In animals with renal insufficiency appropriately reduce the dosage or prolong
the dosing intervals.
As it might cause immunosuppression in animals, therefore it should be cautiously used in the vaccination
【Withdrawal period】14 days for pig and 28 days for chicken.